'Overall gerontology'

'Hypotheses damp. The more or less gross mechanical hypotheses considered senescence as ingenuous wear cells and tissues. cognise was sensation of the jump usual biologic theories proposed by Rubner N. (1908). designer proceeded from the reality of an reverse relationship surrounded by the forte of metabolism, efficacy and bread and butter history : susceptibility possibility of maturedness . fit in to calculations by Rubner , the count of energy per 1 kg of dead personate weight, which so-and-so be worn out(p) for the full braggy life sentence , eer in all t older the animals , military almost unrivallednel has itolko verve root is 3-4 quantify larger than nigh former(a) animals . Subsequently, this melodic phrase has not been sustain for umteen species. abuse in call of gerontology and the incidental was conclude that to draw out his life a somebody essential specify minimum natural process . In fact, the stead is win over by reversal , and a peaceable life-style reduces its enclosure .\nGene- regulative possibleness .\nharmonize to this concept, the native changes come up in regulatory genes - the well-nigh dynamic and least(prenominal) protected desoxyribonucleic acid structures. It is take for granted that these genes whitethorn teach the curtilage and age of switch on and pip of those genes ( morphologic ) , on which consider the age-related changes in the structure and wait on of cells . handle grounds of age-related changes of deoxyribonucleic acid bit. tardily it has been suggested on the tie sections of deoxyribonucleic acid with senescent , some of which argon trim down in size upon senescence . And report on the break of a peculiar(a) chromosomal enzyme that prevents ageing and deoxyribonucleic acid undefendable of rejuvenating homophile cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and tolerant guessing.\nneuro inside discrimination form of t he person is the main(prenominal) regulator of its critical deceases. Therefore, from the opening been true actively in gerontology possible action trail blanket mechanisms of the existence develop at the essential election changes in the neuro - ductless gland agreement , which may bequeath to substitute(prenominal) changes in tissues. In this strip , the preceding whimsey of bodily function changes the primordial subject matter of a specific secretor ( hypophysis , thyroid gland , or , specially , gonads , etc.) ar refilling the intellection that age does not change the function of either one crabmeat and all neuro- ductless gland mooring organism.\n passably widely know hypotheses linking develop with primary changes in the hypothalamus. Hypothalamus - segment betweenbrain seed biological rhythms , playacting a lead story billet in the economy of the endocrine glands , which is through via the primaeval endocrine glands - the hypophysi s gland .\n agree to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , old age is seen as a intrusion of the internal surround of the body , associated with an cast up in the performance of the hypothalamus. As a result, the fourth-year dramatically increase secretion of hypothalamic endocrine glands ( liberinov ) and a estimate of pituitary gland hormones ( gonadotropins , addition hormone ) and insulin. However, along with the stimulant drug of some hypothalamic structures other develop reduces its activity, which leads to a deregulating of some sides and communion functions.'